Roadworks are due to start next week on the slip road between the M61 motorway and the A580 East Lancs Road.
From Friday 22 July for three weeks, new safety gear is being installed along the motorway link, which brings traffic from Bolton south into Swinton and Irlams o’th Height.
Transport for Greater Manchester (TfGM) say they need to install new safety barriers and lighting and will work “as quickly as possible” to get the job done.
Work may need to be done in the daytime, when transport bosses say the the popular route will be reduced to a single lane.
But most work is set for overnight, 11pm to 5am when the slip road will be closed entirely.
Traffic is sure to back up on what are already busy junctions during rush hour.
A spokesperson for TfGM said: “The work in this location will comprises some site clearance, the installation of a new safety barrier, the introduction of additional lining and signing and the installation of new lighting columns.
“Coupled with the newly installed Variable Message Signs (VMS) in this location, the future safety of drivers will be increased as a result of these measures.
“Collectively, TfGM, Highways England and Salford City Council will be communicating the work to drivers across a variety of channels including, VMS on both motorway and highway, social media and in our respective weekly travel bulletins.
“We will endeavour to complete this work as quickly as possible and thank the local community in advance for their patience during this time.”
Work is due to finish by Friday 12 August.