At around 9.30am on Monday 22 June 2015, officers carried out a drugs warrant at an abandoned industrial unit on Hope Street in Higher Broughton.
They found around 600 cannabis plants estimated to be worth around £250,000.
The plants were being grown in several rooms within the unit.
Three men, aged 48, 49 and 51, have been arrested on suspicion of cultivating cannabis and remain in police custody for questioning.
The warrant was carried out as part of Project Gulf, a partnership initiative to reduce serious and organised crime in Salford.
Police Sergeant David LeCheminant from the Project Gulf Team said: “We are continuing to carry out a significant amount of work to tackle drugs and other organised crime in Salford, which today has resulted in the seizure of a large cannabis farm and two men are in custody for questioning.
“Drugs supply and its associated activity is a blight on our communities and we are working hard to crack down on this and make a difference for the people of Salford to make them feel safer and bring those responsible for such crimes to justice.”
Anyone with information on drugs activity in Salford is asked to contact police on 101 or the independent charity Crimestoppers, anonymously, on 0800 555 111.