The M60 clockwise between J17 and J18 at Simister Island is down to one lane after a crash at around 4.30pm.
There is now congestion all the way back to Junction 6 at Sale.
Early estimates of delays have rapidly increased from just 30 minutes to over an hour.
The average speed in sections of the congestion is just 3mph.
Salford Red Devils play Widnes Vikings tonight at the AJ Bell Stadium, off Junction 11 of the M60.
Kick off is at 8pm but drivers are warned to arrive early due to the congestion.
Traffic has been made worse by delays on link roads after a lorry driver miraculously escaped this accident unharmed in Trafford Park earlier this afternoon.