President Xi Jinping and Madame Peng arrived into Manchester Airport on Thursday evening ahead of the Chinese state visit.
They arrived from London Heathrow on a B747-400 ahead of their trip to Manchester and will depart directly to Beijing from Manchester Airport on Friday afternoon.
The government is trying to persuade the Chinese to invest in Greater Manchester.
Several key items are due to be announced today, including the first direct flights between Manchester Airport and Beijing.
Mr Cameron said: “China is a key trading partner for the UK and the partnerships being made today will see real investment going into the north.
“This is all part of this government’s plan to attract more investment and deliver economic growth to an area of huge potential.”