The new two-storey primary school will include a large multi-purpose hall, and a shared teaching space between reception and nursery for combined groups.
The mixed 278-place school was marked ‘Good’ in its most recent Ofsted inspection from June 2014, up from its 2013 rating of ‘Requires improvement’.
Julie Finlay, headteacher, Mesne Lea Primary School said: “The children, staff and Governors are working hard to becoming an outstanding school.
“This new school building will help us to achieve this. The children are excited to see the start of the works and are looking forward to watching the building take shape.”
The school is one of 39 in the North West to be rebuilt under the first phase of the Government’s £2.4 billion Priority School Building Programme.
Schools Minister David Laws said: “The start of construction work at Mesne Lea Primary School marks a key milestone for the Priority School Building Programme in the North West and an exciting phase in the development of the school.
“Delivering great new schools will help to build a stronger economy and a fairer society, so that every young person across the region can get on in life.
“Vital building work is taking place at schools in the worst state across the country.”
55 school buildings are under construction with the remaining 215 in development or planning stages, said Laws.
The work at Mesne Lea Primary School is due for completion by September 2015.